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Best Dermatologist-Recommended Sunscreens for Ultimate Sun Protection Introduction Sun protection is an essential part of skincare, as prolonged exposure to harmful UV rays can lead to sunburn, premature aging and acne. Choosing a high-quality sunscreen that provides broad-spectrum protection is crucial for maintaining healthy and youthful skin. Dermatologists recommend using a well-formulated sunscreen that not only shields against UV damage but also nourishes and hydrates the skin. Among the many sunscreens available in the market, Acnetrol UV Sunscreen stands out as an effective solution. It is designed to provide broad-spectrum UVA and UVB protection while maintaining skin hydration and preventing excess oil production. Its unique blend of active ingredients ensures long-lasting protection and keeps the skin healthy and radiant. Sunscreen is a crucial step in any skincare routine. Daily sun exposure without proper protection can cause various skin concerns, including: Sunburn and irritation Hyperpigmentation and uneven skin tone Premature aging (fine lines and wrinkles) Increased risk of skin cancer   Key active ingredients in Acnetrol UV Sunscreen are dermatologist-approved   Tinosorb M-  Provides broad-spectrum UV protection and ideal for sensitive and acne-prone skin Tinosorb S-  Shields against both UVA and UVB rays and enhances the effectiveness of other sunscreen agents Zinc PCA  -Regulates oil production, making it ideal for oily and acne-prone skin and helps prevent breakouts by reducing excess sebum Sweet Orange Oil - Acts as a natural antioxidant and protects the skin from pollution Vitamin E - A powerful antioxidant that hydrates and soothes the skin and also provide an additional layer of protection against sun damage Sodium Hyaluronate (Hyaluronic Acid) - Prevents dryness caused by prolonged sun exposure and enhances skin plumpness and smoothness Aloe Vera - Calms and soothes sun-exposed skin and  helps maintain a healthy skin barrier   Why Choose Acnetrol UV Sunscreen? Acnetrol UV Sunscreen is specially formulated to offer high sun protection while catering to different skin types, including oily and acne-prone skin. Here’s why it is highly recommended by dermatologists:   Broad-spectrum protection against UVA and UVB rays Non-greasy, lightweight formula that absorbs quickly into the skin Hydrates while controlling excess oil production, making it ideal for acne-prone skin Infused with skin-soothing ingredients that prevent irritation and inflammation Long-lasting sun protection, reducing the need for frequent reapplication     To maximize the benefits of Acnetrol UV Sunscreen, follow these simple steps: Apply a generous amount to your face and neck at least 15 minutes before sun exposure. Reapply every two hours, especially if you are outdoors or sweating. Use sunscreen daily, even when indoors as UV rays can penetrate windows. Do not forget to apply 15 minutes before going out   Sunscreen is an essential investment in your skin’s health. Acnetrol UV Sunscreen is a dermatologist-recommended product that provides broad-spectrum protection while nourishing and hydrating the skin. If you’re looking for a sunscreen that protects, hydrates, and enhances your skin, Acnetrol UV Sunscreen is the perfect choice. Make sun protection a part of your daily skincare routine and enjoy healthy, youthful, and radiant skin every day. Try Acnetrol UV Sunscreen today and experience ultimate sun defense like never before.

Online Consultation with a Skin Specialist: Get Expert Advice from Home   Introduction  Whether you struggle with persistent acne, pigmentation issues or stubborn scars, you do not have to worry anymore! Clinderma’s teleconsultation services bring expert dermatological solutions right to your fingertips, offering personalized treatment plans, expert guidance and effective skincare solutions for various skin concerns. In today’s digital age, accessing expert dermatological advice has never been easier but Clinderma has made it possible just for you! Why Choose Online Dermatology Consultations?   Convenience & Accessibility: No need to travel or wait in long queues. Consult with our dermatologist from anywhere at any time. Expert Dermatologist Advice: Get access to qualified dermatologists who provide evidence-based solutions for acne, pigmentation and scars. Personalized Treatment Plans: Your skin is unique, and so should be your treatment. Clinderma’s dermatologists customize skincare regimens based on your skin type and concerns Safe & Secure Platform: Your medical history and consultation details remain confidential, ensuring privacy and security. Affordable & Time-Saving: Skip expensive in-person visits and save both time and money with cost-effective solutions directly at your door-steps on all days of the week.   Acne Treatment via Teleconsultation Acne is one of the most common skin conditions affecting people of all ages. Whether you suffer from hormonal breakouts, cystic acne or persistent blackheads and whiteheads, Clinderma’s dermatologists assess your skin condition through a detailed virtual consultation. Based on your skin analysis, you will receive: Expert recommendations for topical and oral medications if necessary.  Advice on the right cleansers, moisturizers and sunscreens suited for acne-prone skin. Lifestyle and dietary suggestions to prevent acne flare-ups. Prescription treatments like retinoids, benzoyl peroxide or antibiotics for severe cases. Addressing Pigmentation Issues from Home Uneven skin tone, dark spots and hyperpigmentation can be difficult  to manage without expert guidance. Clinderma’s dermatologists offer tailored treatments to target pigmentation concerns, including: Oral antioxidants and depigmenting medications Creams containing glycolic acid, kojic acid and arbutin Sun protection strategies to prevent further darkening of the skin.   Acne Scar Treatment  Post-acne scars and other blemishes can affect confidence and self-esteem. Through an online consultation, Clinderma’s experts suggest customized scar treatments, including: Topical treatments with retinoids and silicone gels to promote healing. Skincare regimens incorporating exfoliants and collagen-boosting ingredients. Long-term management plans to improve skin texture over time.   How Clinderma’s Teleconsultation Works    Book an Appointment: Schedule a virtual consultation at your convenience by contacting our skin coach. Detailed Skin Assessment: Share images and provide details about your skin concerns. Expert Consultation: A dermatologist evaluates your skin and prescribes a personalized treatment plan. Receive Your Treatment Plan: Get expert guidance on skincare products and lifestyle adjustments.  Follow-Up Sessions: Stay in touch with your dermatologist to track progress and modify treatments as needed.   Why Trust Clinderma for Your Online Skin Consultation? At Clinderma, we are dedicated to providing dermatological expertise through innovative and effective teleconsultation services. Our dermatologists ensure that every consultation results in a precise diagnosis and a well-structured skincare plan tailored to your needs. We focus on treating the root cause of acne and not just superficial acne. Not just that, our treatment plans are comprehensive enough to prevent recurrences as well. Whether you need help managing acne, pigmentation or scars, our expert team is just a click away! Say goodbye to skin worries and welcome healthier, clearer skin,  just a click away !  

Introduction A healthy and hydrated skin is the key to a glowing and youthful appearance. Deep moisturizing creams play a vital role in keeping the skin nourished, soft, and well-protected. Whether you have dry, sensitive, or combination skin, choosing the right moisturizer can make a big difference. Proper hydration not only enhances skin texture but also helps in preventing premature aging, irritation, and environmental damage Why Does Deep Moisturization Matter? Moisturizing is an essential step in any skincare routine. Deep moisturization ensures that the skin retains moisture for long-lasting softness and protection against external stressors like pollution and UV exposure. Using a high-quality deep moisturizing cream helps: Prevent dryness and flaky skin – Keeps the skin soft, supple, and healthy. Lock in moisture for the entire day – Hydrates the skin deeply and prevents moisture loss. Restore and strengthen the skin’s natural barrier – Protects against environmental damage and irritation. Soothe irritation and redness – Calms inflamed skin and reduces sensitivity Reduce the appearance of wrinkles and fine lines – Promotes elasticity for a youthful glow. A good moisturizer contains powerful hydrating ingredients that penetrate deep into the skin. The quality and efficacy of these ingredients matter equally. Squalene Squalene is a natural skin-identical lipid that provides intense hydration without clogging pores, giving it a non-comedogenic property. It mimics the skin’s natural oils, making it perfect for all skin types, including oily and acne-prone skin. It also has antioxidant properties that protect against free radicals and environmental damage, making it an excellent anti-aging ingredient.      2. Hyaluronic Acid Hyaluronic Acid is a well-known ingredient that can hold up to 1,000 times its weight in water. It deeply hydrates the skin, leaving it plump, soft, and radiant, making it look youthful. This ingredient also helps in reducing fine lines and improving skin elasticity, making it essential for maintaining a smooth complexion.     3. Aquaxyl Aquaxyl is an advanced moisture-boosting complex that improves the skin’s water retention ability. It enhances the skin barrier, ensuring long-lasting hydration and smoother skin texture by improving skin suppleness and resilience. This ingredient works at a cellular level to prevent moisture loss, keeping the skin deeply nourished throughout the day. Why Clinderma’s Acnetrol Moisturiser Stands Out? Among the many deep moisturizing creams available, Clinderma’s Acnetrol has a non-greasy, fast-absorbing formula that is designed to provide long-lasting moisture while improving skin texture. It’s ideal for all skin types—dry, oily, and combination, making it suitable for those with acne-prone skin as well.   Why Choose Clinderma’s Moisturiser? Dermatologist-Approved: Formulated with scientifically proven ingredients to ensure safe and effective skincare. Deep Hydration: It is enriched with the chief ingredients—Squalene, Hyaluronic Acid, and Aquaxyl, providing all-day moisture. Non-Greasy Formula: Absorbs quickly, leaving no sticky residue, making it ideal for daily use. Barrier Protection: Strengthens the skin’s natural defense against pollution, dryness, and environmental stressors Soft and Supple Skin: Keeps skin smooth, radiant, and nourished, preventing early signs of aging.   A good deep moisturizing cream is a must-have in your skincare routine. If you’re looking for a lightweight, effective, and skin-friendly moisturizer, Clinderma’s Moisturiser is the perfect choice. With its hydrating and skin-repairing properties, it ensures soft, glowing, and healthy skin all day long.         

Clinderma’s Acnetrol UV Sunscreen- Your best friend against the sun! Many times you experienced your face burning and itching with red rash and irritation while outing, especially on a sunny day, right? The best way to tackle this problem is wearing a good sunscreen over the face. Clinderma’s Acnetrol UV is the best choice for you.   Here is a quick introduction of Clinderma’s Acnetrol UV Sunscreen- Clinderma’s Acnetrol UV Sunscreen is a formulation designed and recommended by dermatologists. It is a hybrid sunscreen having properties of chemical and physical sunscreens, non-comedogenic making it suitable for acne-prone skin and long lasting hydrating properties with the best consistency, leaving no white cast and free from the mess. It has skin brightening properties which fight against suntanning and also protects you from pollution so that you can freely roam around in the sun.  Why is sunscreen important? Clinderma’s Acnetrol UV protects from UVA and UVB rays, which can cause sunburn, premature aging, dark spots and even skin cancer. UV rays lead to collagen breakdown, making your skin dull and aged. Shubham Khandelwal How does it work? It’s a combination of hand-picked ingredients making it extremely ideal for the skin. It gives you broad spectrum protection from UVA and UVB rays, thanks to Octinoxate, Uvinul A, Tinosorb M, Tinosorb S, and Zinc Oxide making it a unique and hybrid formula suitable for all skin types. Vitamin E provides antioxidant effect and Sweet Orange Oil shields from pollution thereby making it extremely comprehensive. Additionally Hyaluronic acid provides deep hydration. So in short, your skin is well protected in all the possible ways from environmental factors. When should I apply? Use it twice-thrice daily covering the entire face and can be applied over other sun-exposed parts of the body whether you are indoors or outdoors.. Apply it compulsorily fifteen- twenty minutes before going out.  Do I need to use any other products with Acnetrol UV? Yes, you must start your routine with Acnetrol Cleanser followed by Acnetrol moisturiser and Acnetrol UV Sunscreen. You can apply just sunscreen later on. Can I use it with makeup products? Absolutely! It’s lightweight and fast absorbing which creates an excellent base for makeup products. Apply it before your foundation and let it settle for a few minutes. Is it water resistant? Yes, it is water and sweat resistant. Can I skip sunscreen if my foundation or moisturiser has SPF? No. SPF in these products is not sufficient to protect your skin from the sun. Always carry Acnetrol UV with you. Are there any side effects of this cream? Yes, minor side effects like, burning, redness, itching and dryness can be there.  How long do I need to apply sunscreen? It can be continued as a part of your daily routine.   Precautions Avoid contact with the eyes and mouth.  Rinse your eyes with plain water if it enters while applying over the face.  Avoid over wounds or raw areas. Always store under a cool and dry place.  Keep out of reach of children   If you need help on how to protect your skin from sun damage, feel free to contact us on:  drsiddharth@theclinderma.com

If you have persistent acne issues, you might have also had dark spots on your face, which is also called PIH ( Post Inflammatory Hyperpigmentation) Oftentimes, once acne is treated, patients want to get rid of their dark spots and pigmentation issues. There are multiple ways dark spots can be treated and one of the very effective ways is by using depigmenting cream. Clinderma’s Epifade is specifically formulated to treat dark spots and other pigmentation problems.   Here is a quick introduction of Clinderma’s depigmenting cream - Epifade Clinderma’s epifade is a potent cream for various common pigmentary conditions like acne marks, melasma, suntanning, etc. Apart from depigmentation, it also promotes uniform skin tone. It contains three chief ingredients- glycolic acid, kojic acid and arbutin making it ideal for fighting against dark spots. It comes as a cream formulation which spreads easily and uniformly over the skin.   It is important to understand the mechanism of action of Epifade cream so that you will understand how it works. Clinderma’s Epifade lightens dark spots by reducing melanin synthesis, as an antioxidant and by sloughing off your superficial skin. So in this way it decreases melanin and sheds off the old dead skin forming a new layer of fresh cells.  When it comes to dosage, it varies patient to patient.  Generally, Clinderma’s Epifade should be used at night or as directed by a dermatologist. It is suitable for the face and other parts of the body.    Few most common questions that we often get asked about the product and its usage  Do I need to use any other products with Epifade? Yes, you must strictly apply Acnetrol moisturiser followed by Acnetrol Sunscreen twice - thrice daily. This can be complemented with Acnetrol Cleanser. What’s the correct sequence of using the Epifade along with other products in the kit? 1 .Acnetrol cleanser: Start with this cleanser to remove dirt, oil, and impurities. 2. Apply Epifade Cream: Apply a small amount on your skin focusing on dark spots and spread it gently. Avoid around eyes and mouth 3. Acnetrol moisturiser- Gently apply moisturiser all over the face followed by sunscreen. 4. Acnetrol Sunscreen: During the day, always use sunscreen to protect your skin, as glycolic acid can increase sun sensitivity. Are there any side effects of this cream? Yes, minor side effects like redness, burning, itching and dryness.  Precautions Avoid around the eyes and mouth. Don’t forget to use moisturiser and sunscreen. Use as directed by the dermatologist as it may cause burning and irritation. Rinse your eyes with plain water if it enters while applying over the face. Avoid over wounds or raw areas. When do you expect the result? Consistent application for at least a month starts showing visible results. However, it also depends on the underlying condition.  How long do I need to use Epifade to see satisfactory results? You must consistently use Epifade for at least 3 months to see satisfactory results. This duration can vary based on the underlying condition. Can I consume oral supplements to see faster results? Yes, you can use them under a dermatologist’s supervision only. What’s next after I complete the course of Epifade? For maintaining the new look and preventing new spots from coming back, you must follow the routine of Acnetrol cleanser, Acnetrol moisturiser followed by Acnetrol Sunscreen twice - thrice daily. Are there any safety precautions that should be taken while using the cream? Always store under a cool and dry place away from the sunlight. To be strictly used under a dermatologist’s supervision only. For use in pregnancy and breastfeeding or in children, always consult your dermatologist.   If you have more questions, you can connect with our dermatologist:  help@theclinderma.com 8447919555

Hey fam! In this edition, we will explore the dual action of Tazarotene 0.045% lotion. This research paper was published in January 2023 in Journal of Dermatological Treatment. Title- Improvements in acne and skin oiliness with tazarotene 0.045% lotion in patients with oily skin. Emil A. Tanghetti, Joshua A. Zeichner, Michael Gold, Neil Sadick, Fran E. Cook-Bolden, Leon H. Kircik, Linda Stein Gold, Jonathan Weiss, Stephen K. Tyring, James Q. Del Rosso & Eric Guenin First Published- 23 January 2023 DOI- 10.1080/09546634.2022.2147391   Tazarotene 0.045%, is a retinoid that not only targets acne but also addresses the persistent challenge of oily skin, a root cause of acne vulgaris.  In this article, we delve into the results of clinical studies and explore how this formulation can be leveraged for treatment of acne. Tazarotene acts primarily by normalizing keratinization, reducing inflammation, and promoting collagen synthesis in the skin. It improves conditions like acne, psoriasis, and photoaging by regulating skin cell turnover, suppressing pro-inflammatory factors, and enhancing collagen production, ultimately leading to smoother, clearer, and healthier skin. Clinical Studies and Acne Reduction  Tazarotene 0.045% lotion underwent rigorous evaluation in two phase 3 clinical trials. The results were promising and transformative as follows: Acne Lesion Reduction: Participants experienced 55% reduction in both inflammatory and noninflammatory acne lesions. This reduction significantly improved overall skin appearance and texture. Notably, patients with moderate-to-severe acne reaped substantial benefits and relief. Oiliness Control and Skin Quality Enhancement Visible Results: Users reported a noticeable decrease in skin oiliness. By week 12, a significant number achieved a ‘low/not oily’ skin status. Texture Transformation: Beyond acne clearance, the lotion enhances skin texture. Safety and Comfort Patient-Centric Approach: Safety matters. Fortunately, tazarotene 0.045% lotion is well-tolerated. Most adverse events were mild and transient, ensuring patient comfort throughout treatment. Conclusion: A New Era in Skincare Tazarotene 0.045% lotion represents a dual-action solution for individuals struggling with acne and oily skin. Not only does it effectively clear acne lesions, but it also enhances skin quality. What's your take on this promising new lotion and how it can be used in the treatment of acne?

Greetings, dear friends! Lets embark on an exploration into the dynamic intersection of skincare and health. In this newsletter edition we will decode the intriguing study exploring the intersection of acne and PCOS. We will explore the significant influence of isotretinoin, elucidating its pivotal role in effectively managing both PCOS and acne This research paper was published in January 2024 in Journal of Ovarian Research. Title- “The impact of oral isotretinoin on ovarian functions of acne patients complaining of polycystic ovarian syndrome: a prospective study” Heba I. Elnagar1, Osama A. Hashem1, Hany O. Aboelwafa2, Ehab Elhelw2 and Mohamed L. Elsaie3 First Published- 20 January 2024 DOI:10.1186/s13048-024-01347-x Introduction: Polycystic ovarian syndrome (PCOS) affects millions of women worldwide, and its symptoms can be distressing. Among these symptoms, acne often takes centre stage, impacting both physical appearance and emotional well-being. However, what if a transformative solution lies within our reach? Enter isotretinoin, a powerful medication that has long been associated with acne treatment. Recent research is shedding light on its potential benefits for PCOS patients. Let’s dive into the science and explore how isotretinoin might revolutionize our approach to managing PCOS-related acne.  The Study: In a prospective clinical trial, researchers evaluated the impact of oral isotretinoin on ovarian functions in women suffering from both acne and PCOS. Here are the key findings: Acne Severity Reduction: Participants experienced a significant reduction in global acne scores after isotretinoin treatment. From pre-treatment levels to post-treatment, the improvement was remarkable. (11.58 ± 5.857 vs. 1.65 ± 1.369). Ovarian Volume: Isotretinoin led to a decrease in ovarian volume on both sides. The right ovary volume decreased from (10.26 ± 1.539 to 8.74 ± 1.436), and the left ovary volume decreased from (11.08 ± 1.564 to 9.36 ± 1.479). Hormonal Changes: Free testosterone levels and hirsutism scores also showed significant reductions after treatment. The Mechanism: Why does isotretinoin work? It’s not just about drying up pimples. This wonder drug: Normalizes Sebaceous Glands: By reducing sebaceous gland secretion, isotretinoin tackles the root cause of acne. Cellular Apoptosis: It induces apoptosis (cell death) in bacterial cells and sebocytes, preventing comedone formation. Anti-Inflammatory Properties: Isotretinoin fights inflammation, reducing  breakouts. Insulin growth factor (IGF-1) - Isotretinoin has been shown to reduce insulin growth factor (IGF-1) that induces the expression of 5-α reductase and converts testosterone to dihydrotestosterone (DHT). DHT is a potent androgen that contributes to the symptoms of PCOS.  Effects on Ovarian Morphology and Function: Isotretinoin exhibits dual actions on ovarian health: Enhancement of granulosa cell apoptosis: Recent research suggests that isotretinoin can promote apoptosis (cell death) of granulosa cells, potentially diminishing the follicular reserve within the ovaries. Inhibition of p53 expression and antiproliferative effect: Isotretinoin inhibits the expression of the tumour suppressor protein p53 and exerts an antiproliferative effect on ovarian stromal cells.  This dual mechanism leads to a reduction in ovarian volume, indicating a potential impact on ovarian function and reproductive health.  Implications and Future Directions: The study’s implications are promising: Hyperandrogenic Women: Isotretinoin may benefit women with PCOS who experience hyperandrogenism. Multicentre Trials Needed: Larger controlled trials are essential to validate these findings and explore isotretinoin’s full potential. Conclusion: In our ongoing quest for effective PCOS management, isotretinoin stands out as a promising solution. Let’s keep our eyes on the research, advocating for better solutions and empowering women to face PCOS with confidence.

Greetings, skincare enthusiasts! 👋 Today, we're delving into an intriguing subject: the battle against atrophic acne scars. Imagine this: we're about to unpack the latest findings from a Phase 4 controlled study freshly published in the December 2023 edition of Dermatology and Therapy. This study dives into how Trifarotene steps up to the plate, aiming to diminish the risk of those stubborn acne scars. So, grab your skincare essentials and get ready for an enlightening journey on how to conquer those blemishes once and for all! 🌟✨  Title - Trifarotene Reduces Risk for Atrophic Acne Scars: Results from A Phase 4 Controlled Study  DOI: 10.1007/s13555-023-01042-7  Published on Dec 2023 Journal – Dermatology and Therapy  Trifarotene isn’t merely a skincare buzzword; it’s a potent ally. In this edition of newsletter  This study underscores its effectiveness in tackling moderate-to-severe facial acne and bidding adieu to atrophic scars. Trifarotene is the most recent topical retinoid to receive regulatory approval for treatment of acne; it has a very low systemic absorption, making it well suited for treatment of large skin areas. Clinical trials of trifarotene included evaluations of both facial and truncal acne and showed efficacy in both areas. In this study, we are looking at the effect of Trifarotene on acne scars. Methods The study was conducted as a randomized, split-face, double-blind trial involving 121 subjects with moderate-to-severe facial acne and atrophic scars. Here’s how the study was designed: Participants: Individuals with both active acne and atrophic scars were recruited. Treatment: Trifarotene was applied to one side of the face, while the other side received a vehicle (placebo) treatment. This split-face design allowed direct comparison. Duration: The treatment was administered once daily for 24 weeks. Assessment Parameters:Atrophic Scar Count: The number of atrophic scars was counted and compared between the two sides.Scar Global Assessment: Researchers evaluated the overall improvement in atrophic scars.Acne Lesion Counts: Both sides were assessed for active acne lesions (papules, pustules, etc.).Investigator Global Assessment: An overall assessment of acne severity. Safety Monitoring: Adverse events were closely monitored. Results The trifarotene-treated side demonstrated significant improvements compared to the vehicle-treated side: Atrophic Scars:Trifarotene led to a greater reduction in total atrophic scar count.Scar global assessment favored the trifarotene-treated side. Acne Vulgaris:Investigator global assessment success rates were higher on the trifarotene-treated side.Acne lesion counts were lower. Safety Profile:Trifarotene was well tolerated, with no serious adverse events reported2. Conclusions Trifarotene is effective in treating moderate-to-severe facial acne and reducing atrophic acne scars. Remarkably, improvements were observed as early as week 2 of treatment. This study highlights the potential of trifarotene as a valuable addition to acne scar management. Remember, if you’re dealing with acne or scars, consult a dermatologist for personalized advice. Takeaways- Trifarotene stands out from other retinoids due to its selective targeting of the retinoic acid receptor gamma (RAR-γ). This distinct mechanism allows trifarotene to offer a more targeted and precise approach to acne management, ultimately reducing the risk of scarring associated with acne.

Hey Skincare Squaddies! Get ready to flip your skincare routine upside down because we've got the inside scoop on the latest breakout star – Clascoterone Cream, 1%! 🌟 Imagine a cream so good, it's like your skin's personal superhero against acne. We're decoding the results of a TWO Phase 3 Randomized Clinical Trials, showcasing the proven efficacy and safety of Clascoterone Cream for treating facial acne. Think of it as the skincare equivalent of a mic drop. 🎤✨ In this edition, we're unpacking the insights from a key research paper: "Efficacy and Safety of Topical Clascoterone Cream, 1%, for Treatment in Patients With Facial Acne." The study was published in June 2020 in journal JAMA dermatology. Acne is a common skin condition that affects millions of people worldwide, especially adolescents and young adults. It can cause physical and psychological distress, as well as scarring and infection. Current treatments for acne include topical and oral medications, such as antibiotics, retinoids, and hormonal agents, but they may have limited efficacy or undesirable side effects. A new topical cream, clascoterone, may offer a novel and safe alternative for acne treatment. Clascoterone is a synthetic androgen receptor inhibitor that works by blocking the effects of dihydrotestosterone (DHT), a hormone that stimulates sebum production and inflammation in the skin. Two phase 3 randomized clinical trials, conducted by Hebert et al, evaluated the efficacy and safety of clascoterone cream, 1%, compared with vehicle cream in patients with facial acne. The trials enrolled a total of 1440 patients aged 9 years or older with moderate to severe acne, who applied clascoterone or vehicle cream twice daily for 12 weeks. The results showed that clascoterone cream, 1%, was significantly more effective than vehicle cream in reducing the number of inflammatory and noninflammatory lesions, as well as achieving treatment success, defined as clear or almost clear skin. Clascoterone cream, 1%, was also well tolerated, with no serious adverse events or systemic absorption reported. The authors concluded that clascoterone cream, 1%, is a promising new topical therapy for acne that targets the androgen receptor pathway, without causing hormonal imbalance or systemic side effects. They suggested that clascoterone cream, 1%, could be used as monotherapy or in combination with other acne treatments, such as benzoyl peroxide or antibiotics. What's your take on this promising new molecule in treatment of acne ?

Hey fam! 👋 Let’s dive into an exciting topic today.  In this edition we are exploring the fascinating world of ceramide and niacinamide-containing moisturizers (CCM) and their impact on acne treatment. We will be gathering insights by decoding the research paper titled “Efficacy of ceramides and niacinamide- containing moisturizer versus hydrophilic cream in combination with topical anti- acne treatment in mild to moderate acne vulgaris: A split face, double- blinded, randomized controlled trial” This research paper was published  in February 2024  Journal of Cosmetic Dermatology.  Get ready for some skin science! 🌟✨ Title- Efficacy of ceramides and niacinamide- containing moisturizer versus hydrophilic cream in combination with topical anti- acne treatment in mild to moderate acne vulgaris: A split face, double- blinded, randomized controlled trial” Therdpong Tempark M.D., Andrew Shem M.D., MSc, Suparuj Lueangarun M.D., MSc Date: First published: 01 February 2024  DOI: https://doi.org/10.1111/jocd.16212 Acne is a common skin condition that affects many people, especially adolescents. Topical therapy with retinoids and benzoyl peroxide is the first-line treatment for mild to moderate acne, but it can cause skin irritation and dryness. Moisturizers are often recommended to reduce these side effects and enhance the efficacy of acne treatment. Key highlights from the Study The study compared the effects of two different moisturizers in combination with topical anti-acne treatment in 40 patients with mild to moderate acne. One moisturizer contained ceramides and niacinamide, which are ingredients that can improve skin barrier function, hydration, and inflammation. The other moisturizer was a hydrophilic cream without these ingredients. The patients applied the moisturizers on each half of their face, along with 5% benzoyl peroxide in the morning and 0.1% adapalene gel at night, for 8 weeks. The Results The results showed that the ceramides and niacinamide moisturizer (CCM) significantly reduced the number of non-inflammatory, inflammatory, and total acne lesions compared to the hydrophilic cream after 8 weeks of treatment.  The CCM also prevented the flare-up of inflammatory lesions that often occurs with topical retinoids. Both moisturizers improved the skin tolerance and reduced the irritation caused by the anti-acne medications The authors concluded that CCM in combination with anti-acne medication can improve acne lesions and decrease cutaneous irritations, leading to a better treatment outcome for mild to moderate acne.  They suggested that ceramides and niacinamide may have beneficial effects on acne by restoring the skin barrier, reducing inflammation, and regulating sebum production. However, they also acknowledged some limitations of their study, such as the small sample size the lack of long-term follow-up etc. This study provides evidence that moisturizers with specific ingredients can enhance the effectiveness and tolerability of topical acne therapy. Takeaways: -  his combination can be tried with mild to moderate cases of acne, but further studies with large sample sizes are recommended.

Hey ! Hope this message finds you in the land of good vibes and happy tummies! 🌈✨ Today, we're diving into a topic that's all about that gut feeling – and no, we're not talking about trusting your instincts during awkward social encounters (although, that's important too!). Grab your favorite mug of kombucha or a yogurt parfait, because we're about to embark on a journey through the fascinating world of probiotics and gut health. It's like a mini vacation for your belly, and who doesn't love a happy, well-balanced stomach, right? So, picture this: your gut is like a bustling city, complete with its own community of trillions of microorganisms throwing a party 24/7. And guess what? Probiotics are the cool cats invited to keep the vibe positive and the digestion dance floor grooving. But, before we get all science-y, let's keep it chill. Imagine your gut as the VIP lounge, and probiotics are the bouncers making sure only the good vibes get in. They're the unsung heroes working behind the scenes to keep your digestive system running smoother than your favorite playlist. In this edition of d'acnelab review, we're decoding a research paper that talks about the role of gut health in the skin health The research study was published in 2023, conducted at Department of Nutrition and Health, China Agricultural University, Beijing 100083, China Study title: The Role of Probiotics in Skin Health and Related Gut–Skin Axis: A Review Date - July, 2023 DOI - https://doi.org/10.3390/nu15143123   The paper explores probiotic applications in skincare, including whitening, moisturizing, anti-aging, anti-wrinkle, and body odor removal. It delves into the mechanisms, providing a theoretical foundation for future probiotic applications in skincare. The intersection of dermatology and microbiology has unveiled probiotics as a groundbreaking ingredient in skin care. The article we’re examining offers an in-depth analysis of the multifaceted ways in which these microorganisms contribute to skin vitality. The Gut-Skin Axis: A Bidirectional Pathway The gut-skin axis represents a bidirectional communication channel where the gut microbiota and the skin influence each other. This relationship implies that a balanced gut microbiome can lead to a healthier skin appearance. Probiotics, known for their ability to restore gut flora equilibrium, can thus play a pivotal role in managing skin health. Probiotics’ Multifaceted Role in Skin Care Probiotics’ influence extends beyond gut health, with several key functions in skin care: Antioxidant Activity: Probiotics can enhance the skin’s resilience against environmental aggressors, mitigating oxidative damage and promoting a youthful glow. Anti-Inflammatory Properties: By modulating the immune response, probiotics can alleviate symptoms of inflammatory skin disorders, offering a soothing effect. Immune System Support: A balanced skin microbiome, maintained by probiotics, is essential for warding off harmful pathogens and maintaining overall skin health. The skin improvement effect of probiotics and its related mechanism Innovative Applications: Probiotics in Cosmetic Formulations The cosmetic industry is increasingly recognizing the potential of probiotics, incorporating them into various products for their unique benefits: Complexion Enhancement: Probiotics can regulate melanogenesis, leading to reduced pigmentation and a brighter complexion. Skin Hydration: By fortifying the skin’s barrier, probiotics help lock in moisture, combating dryness and enhancing skin texture. Wrinkle Reduction: The stimulation of collagen synthesis by probiotics can lead to firmer, smoother skin, diminishing the signs of aging. Odor Management: Probiotics can enzymatically decompose sweat molecules, effectively reducing body odor without disrupting the skin’s natural flora. Research Insights: The Promising Horizon for Probiotics The article emphasizes the flourishing  field of probiotic research in dermatology. With a growing body of evidence supporting their efficacy, probiotics are poised to revolutionize skin care practices. The Future of probiotics is skincare As research continues to evolve, the potential for probiotics in skin care looks promising. With their ability to address a wide array of skin concerns, probiotics are destined  to become a staple in both topical and ingestible skin care products. Expanded Takeaways: A Closer Look Probiotics are not just beneficial for gut health; they are also proving to be a valuable asset in skin care, with a direct impact on skin quality and appearance. The gut-skin axis serves as a critical pathway for the effects of probiotics on the skin, highlighting the importance of internal wellness for external beauty. Through their antioxidant, anti-inflammatory, and immune-supportive actions, probiotics can address a wide range of skin concerns. The dermatology industry is exploring new ways to harness the power of probiotics, leading to innovative products that offer brightening, hydrating, anti-aging, and deodorizing effects. Ongoing and future research into probiotics will likely uncover even more applications and benefits, solidifying their role in the advancement of skin care solutions.   And there you have it, our deep dive into the world of gut health and probiotic magic! Remember, your gut is a superstar, so treat it with the love and care it deserves. Stay tuned for more exciting revelations and wellness nuggets in our next newsletter. Until then, be kind to your gut, embrace those good microbes. Wishing you a world of well-being,

Hello !   This newsletter, we will be decoding a very recent research study that was conducted in March 2023 at Pomeranian Medical University in Szczecin, Poland. Study title - Metabolic and Dietary Factors in Acne Vulgaris and Evaluation of the Acne Vulgaris Treatment with Oral Contraceptive-Based Therapies in Young Adult Women Date - March 2023 DOI: 10.3390/nu15061488   Acne, a familiar skin woe, often makes its presence felt during the tumultuous years of youth. Beyond just a cosmetic concern, it significantly influences both physical and mental well-being. Recent research delves into the intricate web of factors contributing to acne, shedding light on the nexus between endocrine (hormonal), nutritional, and dietary elements. Metabolic Dance of Hormones A study published in Nutrients (2023) set out to explore the metabolic aspects of acne, focusing on 168 women aged 18-31. Divided into two groups - one with acne and another without - the study unearthed intriguing links between insulin resistance and acne. In the acne-afflicted group, insulin levels and the HOMA-IR index (reflecting insulin resistance) were notably higher. Insulin resistance, often associated with increased androgen production, triggers excess sebum secretion and skin inflammation, contributing to acne development. Additionally, the study found lower levels of "good" cholesterol, hinting at dyslipidemia playing a role in acne by affecting skin barrier function. Navigating the Dietary Maze Turning the spotlight onto diet, the research probed the impact of high glycemic index (GI) foods, particularly sweets, on acne severity. The study established a significant correlation between sweet consumption and acne severity, measured using the Leeds scale. High-GI diets can elevate insulin and IGF-1 levels, fueling androgen production, sebum secretion, and skin inflammation. Surprisingly, while dairy products are often implicated in acne, this study didn't find a significant correlation. It's worth noting that individual variations or the specific types of dairy consumed might contribute to this nuanced picture. Contraceptive-based Therapies: Allies in Acne Battle The study also evaluated the effectiveness of oral contraceptive-based therapies in mitigating acne severity in young women.  The study group was further divided into subgroups according to the treatment used: Oral contraceptive (OC), Oral contraceptive and cyproterone acetate (OC+A),  3)   Oral contraceptive and isotretinoin (OC+R). Regardless of the specific treatment (OC, OC+A, OC+R), all three significantly reduced acne severity after a six-month follow-up. This underscores the efficacy of oral contraceptives in managing acne, with no substantial difference noted between the treatments. Strikingly, the study suggested that these contraceptive-based therapies might mitigate the impact of diet on acne, implying a potential avenue for managing acne beyond dietary modifications. In a Nutshell: Key Takeaways Hormonal Havoc: Insulin resistance and higher insulin levels might be pivotal players in the acne game among young women. Dietary Dynamics: Sweets, with their high glycemic index, seem to exacerbate acne severity, while the link with dairy products appears more complex. Contraceptive Chronicles: Oral contraceptives, with or without additional agents, emerge as effective tools in taming acne, potentially transcending the influence of diet. Conclusion: Toward Clearer Skin In essence, this study beckons us to recognize the intricate interplay of hormones, diet, and acne. Oral contraceptives, by offering a viable solution, provide hope for those grappling with acne-related challenges. As we navigate this terrain, the call for further studies resonates, urging us to deepen our understanding of these connections and pave the way for more effective acne management strategies. For now, the message is clear – A comprehensive approach that integrates hormonal and dietary considerations, along with a personalized treatment protocol, rather than a one-size-fits-all method, could be pivotal in achieving improved therapeutic outcomes Well, here is something to ponder over-  Multiple drugs can be avoided for management of acne by personalized treatment protocol to reduce the cost as well as increase the compliance for the patients. What was your experience in management of acne ?